En forgiftning viser sig ofte umiddelbart ved kvalme og opkastninger. En leverskade viser sig derimod først efter nogle dage, med blandt andet påvirkning af hjernen.De aktive stoffer buprenorphin og nalbuphin er midler der virker som de andre syntetiske opioider, men de har desuden en modsatrettet virkning, idet de også spærrer for andre opioid

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